Solihull Liberal Democrat MP Lorely Burt has joined forces with the Royal National Institute of Blind People, Guide Dogs, and Action for Blind People to petition the council over its plans for Solihull Gateway.
The charities believe the current plans for a 'Shared Space' in which pedestrians and traffic move freely together could endanger blind and partially sighted people.
Lib Dem activists launched the joint petition with charity campaigners at a Guide Dogs fund-raising stall on Solihull High Street.
They are calling for two crossings on Poplar Road to be preserved to make sure visually impaired people have safe places to cross.
Residents can sign the petition online at http://tinyurl.com/lypsp7n.
Mrs Burt said, "The plans as they currently stand pose serious risks for people with difficulty seeing.
"I very much hope that Conservative councillors will listen to advice from local charities and live up to their responsibilities to vulnerable people in Solihull.
"The last thing anyone wants is a preventable accident at the new Solihull Gateway development."
Rebecca Swift, RNIB Regional Campaigns Officer, said, "If the current proposal to remove this crossing were to go ahead, it would mean that many blind and partially sighted people would no longer be able to navigate this area of Solihull safely and independently.
"We are calling on the council to keep the crossing and to ensure that Solihull town centre is as accessible and inclusive as possible."